Endocrine Abstracts

Background: For many years testosterone therapy in men was considered to be a risk factor for increasing the PSA level and prostate volume as well as blood count parameters. Objective was to investigate the influence of testosterone therapy on prostate and blood count in men with metabolic syndrome and hypogonadism.Methods: In a randomized, placebo-controlled, double-blind, phase III trial (ClinicalTrials.gov identifier: NCT00696748), 184 men suffering f...

Context: Low testosterone level in men is associated with the metabolic syndrome (MetS) as well as with depressive symptoms, low vitality and sexual dysfunction.Objective: To assess the effects of testosterone administration on these subjective symptoms, which have not extensively been studied in hypogonadal men with the MetS. Design: randomized, placebo-controlled trial. Setting: academic, ambulatory, referral centre. Patients: 184 men suffering from bo...

Background: Metabolic syndrome has a high prevalence in male population, leading to the high rate of cardiovascular disease and mortality. Numerous studies show that low androgen levels in men are associated with the metabolic syndrome. This study tested whether normalization of testosterone levels improves metabolic dysregulations and body composition.Methods: In a randomized, placebo-controlled, double-blind, phase III trial (ClinicalTrials.gov identif...

Background: Numerous studies (among which, studies of androgen deprivation in men with prostate cancer) show that low androgen levels in men are associated with the metabolic syndrome. Obesity and particularly visceral fat excess is associated with pro-thrombotic and pro-inflammatory states as well. This study tested whether normalization of testosterone levels improves markers of inflammation.Methods: In a randomized, placebo-controlled, double-blind, p...